The Isley Brothers are an American musical group originally from Cincinnati, Ohio, originally a vocal trio consisting of brothers O'Kelly Isley, Jr., Rudolph Isley and Ronald Isley. The group has been cited as having enjoyed one of the "longest, most influential, and most diverse careers in the pantheon of popular music".

Alongside a fourth brother, Vernon, the group originally performed gospel music until Vernon's death a few years after its original formation. After moving to the New York City area in the late 1950s, the group had modest chart successes during their early years, first coming to prominence in 1959 with their fourth single, "Shout", written by the three brothers. Initially a modest charted single, the song eventually sold over a million copies. Afterwards the group recorded modestly successful works for a variety of labels, including the top 20 single, "Twist and Shout" and the Motown single, "This Old Heart of Mine (Is Weak for You)" before recording and issuing the Grammy Award-winning hit, "It's Your Thing" on their own label, T-Neck Records.

Throughout their career, the Isley Brothers have had four Top 10 singles on the United States Billboard chart. Sixteen of their albums charted in the Top 40. Thirteen of those albums have been either certified gold, platinum or multi-platinum by the RIAA. The brothers have been honored by several musical institutions including being inducted to the Rock and Roll Hall of Fame in 1992. Five years later, they were inducted to Hollywood's Rockwalk and in 2003, were inducted to the Vocal Group Hall of Fame.

Below is a list of Isley Brothers songs, sorted by the most popular first. Place mouse on to see information about song. Click song title to play song and to read details about the song including lyrics (if available). Click year to list all songs from that year. Click label to list songs from that record label. Songs with chart position "---" either never made it into the US top 100 R&B or UK charts or we have no details of their highest chart positions if they did.

(Song are sorted in highest US R&B Top 100 and/or UK Top 100 chart position order)